What is Invokana (Canagliflozin) used for?
Invokana (Canagliflozin) helps with glycemic control in adults with type-2 diabetes mellitus. It is classified as a sodium-glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin decreases the amount of sugar absorbed by the body and increases the amount of sugar excreted in the urine.
How should I use Invokana (Canagliflozin)?
Invokana is available in strip of 10 tablets. Each tablet contains 100mg of canagliflozin.
The recommended starting dose of Invokana is 100mg daily taken before the first meal of the day. Blood tests will be taken to ensure adequate levels if glycemic control are being reached. If needed, dosages can be increased up to a maximum of 300mg daily.
Invokana should be used as an adjunct to diet and exercise for best results.
What are the side effects of Invokana (Canagliflozin)?
The most commonly reported side effect during clinical studies was genital mycotic infections in female patients. Genital mycotic infections were also reported in male patients, however they were less common.
Other reported side effects included:
In the post-marketing period there have been reports of bone fractures and a higher risk of falls during the first few weeks of treatment with canagliflozin.
Canagliflozin is contraindicated in anybody who is hypersensitive to sodium-glucose cotransporter 2 (SGLT2) inhibitors, people with severe renal impairment or with end-stage renal disease, and in patients on dialysis.
Canagliflozin can cause dizziness, light-headedness or fainting. Do not drive a car or operate machinery until you know how canagliflozin affects you.
Alcohol has a moderate interaction with canagliflozin and can affect blood glucose levels.
Canagliflozin is listed as Pregnancy Category C. It is not known if canagliflozin is passed through breastmilk.
Tell your doctor if you have kidney or liver problems, low or high blood pressure, high cholesterol, or high potassium blood levels before using Invokana.
Some medicines can have interactions with canagliflozin. ACE (angiotensin-converting enzyme) inhibitors, phenytoin, phenobarbital, rifampin, ritonavir, digoxin or any other diabetic medications are the most important. Make sure your doctor is aware of any drugs you are taking before beginning treatment with canagliflozin.