What is Parit (Rabeprazole) used for?

Parit (Rabeprazole) is an antiulcer agent and is used to treat stomach ulcers and duodenal ulcers. Its action is based on the inhibition of H+/K+-ATPase, or the proton pump. It helps block the last stage of the hydrochloric acid synthesis.

Parit (Rabeprazole) reduces the production of hydrochloric acid by stomach cells and is effectively used to fight Helicobacter pylori, which in most cases causes ulcers. It inhibits both basal and stimulated hydrochloric acid production. During the course of treatment, its effect, i.e. the reduction in the acid levels, depends on the dose. After the treatment, the natural body function is fully restored.

Single 20mg dose causes hydrochloric acid production inhibition in 1 hour and reached its peak action within 2-4 hours. The general duration of the production inhibition lasts for up to 48 hours.

How should I use Parit (Rabeprazole)?

Parit (Rabeprazole) tablets are taken by mouth, swallowed whole, 1 tablet once daily before breakfast. Depending on the disease, the treatment regimen may be one of the following:

• For ulcer in the exacerbation phase: 4-8 weeks, sometimes up to 12 weeks.
• For gastroesophageal reflux disease: 4-8 weeks, and subsequent maintenance treatment 1 tablet (10-20mg) once daily.
• For Zollinger-Ellison syndrome: the treatment regimen is prescribed individually to each patient, on a case by case basis.
• For Helicobacter pylori infection: the medication is used as part of the eradication treatment in combination with antibiotics for 1 week.

Before starting the treatment, any malignant tumors in stomach have to be ruled out. Patients, taking Parit (Rabeprazole) on a long-term basis (over a year), are subject to regular check-ups.

What are the side effects of Parit (Rabeprazole)?

Parit (Rabeprazole) may cause the following side effects:

• Gastro-intestinal tract - pain, nausea, diarrhea, constipation, flatulence, high liver transaminases, dry mouth. Very rare - stomatitis, loss of appetite.
• Nervous system and sense organs - dizziness, asthenia, headache, drowsiness. Rare - vision and taste disorders, depression.
• Hematopoietic system - leucopenia, thrombocytopaenia.
• Musculo-skeletal system - joint pain, muscle pain, calf cramps.
• Respiratory system - rhinitis, pharyngitis. Rare - sinusitis, cough.
• Allergic reactions - skin rash.
• Other effects - fever, back pain, flu-like syndrome. Rare - increased sweatiness, weight gain.

Please Note

Parit (Rabeprazole) is contraindicated in the following cases:

• Hypersensitivity to the components of the medication or other medications classified as substituted benzimidazole;
• Malignant tumors in duodenum or stomach.