What is Sofosvel (Sofosbuvir/Velpatasvir) used for?

Sofosvel is a treatment for Chronic Hepatitis C (HCV), and can has very high cure rates for all HCV genotypes. Sofosvel is a fixed-dose combination of sofosbuvir (a hepatitis C virus (HCV) nucleotide analog NS5B polymerase inhibitor) and Velpatasvir (an HCV NS5A inhibitor).

How should I use Sofosvel (Sofosbuvir/Velpatasvir)?

Sofosvel is a combination tablet containing 400mg of Sofosbuvir and 100mg of Velpatasvir. Each pack contains 6 tablets.

The most common dosage prescribed is one tablet of Sofosvel daily. This is taken for a 12-week period. In some patients (for example, patients with renal impairment or renal disease) the dosage may need to be adjusted.

For treatment of Chronic Hepatitis C (HCV) without cirrhosis or with compensated cirrhosis (Child-Pugh A), Sofosvel is taken alone.

For treatment of Chronic Hepatitis C (HCV) with decompensated cirrhosis (Child-Pugh B and C), Sofosvel is taken in combination with ribavirin.

What are the side effects of Sofosvel (Sofosbuvir/Velpatasvir)?

The most common side effects of Sofosvel are headache and tiredness. If taken in combination with ribavirin other common side effects are anemia, nausea, insomnia, and diarrhea.

When Sofosvel is used in combination with medicines containing amiodarone it can lead to serious side effects including slowing of the heart rate. This can result in death or need of a pacemaker. If you are taking these medicines in combination, tell your doctor immediately if you notice fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.

Please Note

• of any medical conditions you have (especially any other liver problems or kidney problems)
• if you are pregnant or trying to become pregnant
• if you are breastfeeding or planning to breastfeed
• if you are taking any medicines, especially any products containing tenofovir disoproxil fumarate or amiodarone