Active Ingredient	Chlorambucil
Manufacturer	Aspen
Origin	India
Reference	N/A

What is Leukeran (Chlorambucil) used for?

Leukeran contains the active ingredient Chlorambucil. Chlorambucil is an alkylating agent used in the treatment of leukemia and lymphoma. Sometimes Leukeran can help treat certain blood disorders or kidney problems. Leukeran works by slowing or stopping the growth of cancer cells.

How should I use Leukeran (Chlorambucil)?

Leukeran tablets each contain 2mg of Chlorambucil. It is sold as a bottle of 25 tablets.

Individual dosages may vary from person to person based on factors such as weight and treatment response. A common starting dosage is 0.1mg to 0.2 mg per kg of body weight, taken daily for 3 to 6 weeks as required.

Follow all instructions provided by your doctor.

Leukeran is an oral (by mouth) tablet.

Chlorambucil may be better suited to being taken in short courses, rather than continuous maintenance therapy.

What are the side effects of Leukeran (Chlorambucil)?

The most common side effects of Chlorambucil are:

• bone marrow suppression (this can usually be reversed if treatment is stopped early enough)
• anemia
• leukopenia
• neutropenia
• thrombocytopenia
• pancytopenia

Other side effects you may experience include:

• gastrointestinal upset (nausea, vomitting, diarrhea)
• tremors / muscle twitching
• myoclonia
• confusion
• agitation
• ataxia
• hallucinations
• allergic reactions
• pulmonary fibrosis
• hepatotoxicity and jaundice
• drug fever
• peripheral neuropathy
• interstitial pneumonia
• sterile cystitis
• infertility
• leukemia and secondary malignancies

If you notice any of the above side effects while taking Chlorambucil, contact your doctor immediately.

Please Note

Chlorambucil is a carcinogenic substance. Only take Leukeran for chronic cases of lymphatic leukemia or malignant lymphomas. Convulsions, infertility, leukemia, and secondary malignancies have been observed when chlorambucil was used.

Chlorambucil can damage chromatids or chromosomes in humans. Reversible and permanent sterility have both also been observed in patients receiving chlorambucil.

Leukeran a Pregnancy Category D medicine. It can cause fetal harm when administered to a pregnant woman. Advise your doctor if you are pregnant or trying to become pregnant. In case of accidental pregnancy while taking Chlorambucil, contact your doctor as soon as you become aware of this.

Breast feeding is not recommended while taking Leukeran as it may be passed to the baby through the milk.

Leukeran can cause significant changes to blood cell counts, particularly to lymphocytes and neocytes, which in turn can cause irreversible bone marrow damage.

Chlorambucil should not be taken until at least 4 weeks after chemotherapy or radiation.